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Sangram S Sisodia Selected Research

Flavin-Adenine Dinucleotide (FAD)

1/2021An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo.
1/2019Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
3/2014Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons.
5/2013Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.
12/2010Activation and intrinsic gamma-secretase activity of presenilin 1.
5/2010Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.
8/2008Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
11/2007Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
6/2007Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
2/2006Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
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Sangram S Sisodia Research Topics

Disease

45Alzheimer Disease (Alzheimer's Disease)
10/2021 - 01/2002
6Amyloidosis
01/2022 - 05/2013
5Amyloid Plaque
02/2014 - 01/2002
3Colorectal Neoplasms (Colorectal Cancer)
07/2005 - 08/2003
2Gliosis
01/2019 - 01/2017
2Dementia (Dementias)
11/2007 - 01/2002
1Neuroinflammatory Diseases
09/2021
1Cognitive Dysfunction
01/2020
1Memory Disorders (Memory Loss)
01/2019
1Inflammation (Inflammations)
01/2016
1Breast Neoplasms (Breast Cancer)
08/2014
1Hypoxia (Hypoxemia)
08/2014
1Neoplasm Metastasis (Metastasis)
08/2014
1Lewy Body Disease (Lewy Body Dementia)
11/2007
1Neuroblastoma
02/2005
1Malformations of Cortical Development
07/2004

Drug/Important Bio-Agent (IBA)

16Peptides (Polypeptides)IBA
01/2021 - 01/2002
14Presenilin-1IBA
01/2019 - 01/2002
14Amyloid Precursor Protein Secretases (beta-Secretase)IBA
03/2016 - 04/2002
13Amyloid (Amyloid Fibrils)IBA
10/2021 - 01/2002
12Flavin-Adenine Dinucleotide (FAD)IBA
01/2021 - 01/2003
10PresenilinsIBA
01/2020 - 01/2002
9Amyloid beta-PeptidesIBA
09/2010 - 01/2002
8Proteins (Proteins, Gene)FDA Link
10/2021 - 01/2002
4Anti-Bacterial Agents (Antibiotics)IBA
01/2020 - 01/2016
3Presenilin-2IBA
03/2014 - 01/2002
1Macrophage Colony-Stimulating FactorIBA
01/2022
1Apoptosis Regulatory ProteinsIBA
09/2021
1Anti-Infective Agents (Microbicides)IBA
01/2020
1Transcription Factors (Transcription Factor)IBA
08/2014
1EnzymesIBA
08/2014
1AcidsIBA
02/2014
1Bexarotene (LGD1069)FDA Link
05/2013
1Pharmaceutical PreparationsIBA
05/2013
1BMS 708163IBA
09/2012
1Membrane Proteins (Integral Membrane Proteins)IBA
06/2011
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2010
1ChemokinesIBA
01/2010
1LDL Receptors (LDL Receptor)IBA
11/2008
1CathepsinsIBA
10/2008
1CalpainIBA
10/2008
1Codon (Codons)IBA
11/2007
1alpha-SynucleinIBA
11/2007
1Threonine (L-Threonine)FDA Link
11/2007
1Insulysin (Insulin-Degrading Enzyme)IBA
08/2007
1Insulin (Novolin)FDA Link
08/2007
1ZincIBA
08/2007
1Metalloproteases (Metalloproteinases)IBA
08/2007
1CalciumIBA
11/2006
11-dodecylpyridoxal (PLD)IBA
02/2006
1phospholipase D1IBA
02/2006
1Detergents (Detergent)IBA
07/2005
1Cadherins (E-Cadherin)IBA
07/2005
1Gamma Secretase Inhibitors and ModulatorsIBA
02/2005
1DNA (Deoxyribonucleic Acid)IBA
02/2005
1Aspartic Acid ProteasesIBA
02/2003
1L 685458IBA
02/2003

Therapy/Procedure

1Fecal Microbiota Transplantation
01/2022
1Therapeutics
01/2020
1Oral Administration
09/2010